Retention of basic fibroblast growth factor immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrast with loss in Parkinson's disease
Identifieur interne : 004213 ( Main/Exploration ); précédent : 004212; suivant : 004214Retention of basic fibroblast growth factor immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrast with loss in Parkinson's disease
Auteurs : I. Tooyama [Canada, Japon] ; E. G. Mcgeer [Canada] ; T. Kawamata [Canada, Japon] ; H. Kimura [Japon] ; P. L. Mcgeer [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1994.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adolescent, Adult, Age, Aged, Aged, 80 and over, Aging, Aging (metabolism), Aging (pathology), Basic fibroblast growth factor, Dopamine (metabolism), Dopaminergic neuron, Exploration, Female, Fibroblast Growth Factor 2 (metabolism), Human, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Locus niger, Male, Middle Aged, Neurons (metabolism), Neurotrophic factor, Oculomotor Nerve (cytology), Oculomotor Nerve (physiology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, Substantia Nigra (cytology), Substantia Nigra (growth & development), Substantia Nigra (metabolism), Substantia nigra.
- MESH :
- chemical , metabolism : Dopamine, Fibroblast Growth Factor 2.
- cytology : Oculomotor Nerve, Substantia Nigra.
- growth & development : Substantia Nigra.
- metabolism : Aging, Neurons, Parkinson Disease, Substantia Nigra.
- pathology : Aging, Parkinson Disease.
- physiology : Oculomotor Nerve.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Male, Middle Aged.
Abstract
A count of pigmented neurons per mm3 in sections of the substantia nigra at the level where the oculomotor nerve emerges in 11 neurologically normal controls aged 15–82 showed the expected slow loss of such neurons with age. Most (82±3.8%) of the pigmented neurons showed immunoreactivity for basic fibroblast growth factor (bFGF) and this percentage was unaffected by age. This is a marked contrast to the case in Parkinson's disease where only some 12.7±2.6% of the remaining dopaminergic neurons showed bFGF-like immunoreactivity, providing further evidence against the hypothesis that Parkinson's disease is due to some early insult followed by age-related attrition of the remaining neurons.
Url:
DOI: 10.1016/0006-8993(94)91378-1
Affiliations:
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Le document en format XML
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Most (82±3.8%) of the pigmented neurons showed immunoreactivity for basic fibroblast growth factor (bFGF) and this percentage was unaffected by age. This is a marked contrast to the case in Parkinson's disease where only some 12.7±2.6% of the remaining dopaminergic neurons showed bFGF-like immunoreactivity, providing further evidence against the hypothesis that Parkinson's disease is due to some early insult followed by age-related attrition of the remaining neurons.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Japon</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Tooyama, I" sort="Tooyama, I" uniqKey="Tooyama I" first="I." last="Tooyama">I. Tooyama</name></noRegion><name sortKey="Kawamata, T" sort="Kawamata, T" uniqKey="Kawamata T" first="T." last="Kawamata">T. Kawamata</name><name sortKey="Mcgeer, E G" sort="Mcgeer, E G" uniqKey="Mcgeer E" first="E. G." last="Mcgeer">E. G. Mcgeer</name><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P. L." last="Mcgeer">P. L. Mcgeer</name></country><country name="Japon"><noRegion><name sortKey="Tooyama, I" sort="Tooyama, I" uniqKey="Tooyama I" first="I." last="Tooyama">I. Tooyama</name></noRegion><name sortKey="Kawamata, T" sort="Kawamata, T" uniqKey="Kawamata T" first="T." last="Kawamata">T. Kawamata</name><name sortKey="Kimura, H" sort="Kimura, H" uniqKey="Kimura H" first="H." last="Kimura">H. Kimura</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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